Comparison of CRP with blood culture in the diagnosis of neonatal septicaemia

Original Article

Author Details : Abha Gupta, Dharmendra Rajput, Sadhna Sodani*, Anita Mutha

Volume : 7, Issue : 4, Year : 2020

Article Page : 327-329

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Introduction: In neonates, septicaemia is one of leading cause of morbidity and mortality. Therefore, timely diagnosis is important to prevent fatal outcome. C-reactive protein is an important biomarker that aids in the timely diagnosis of neonatal septicaemia.
Aim: The present study was carried out to compare the accuracy of CRP in the diagnosis of neonatal septicaemia with blood culture.
Materials and Methods: 148 neonates diagnosed with neonatal sepsis were included in the study over a period of 6 months. Blood culture and semi-qualitative assessment of CRP was done for all the patients.
Results: Of the 148 neonates studied, 53 were blood culture positive while 101 were CRP positive. The sensitivity, specificity, positive and negative predictive values and diagnostic accuracy of CRP were 86.7%, 43%, 45.5%, 85% and 69% respectively.
Conclusion: The specificity and sensitivity of CRP against blood culture strengthen the use of this acute phase protein in the diagnosis of neonatal sepsis.

Keywords: Osteomyelitis, Gastroenteritis, Pyelonephritis, Endocarditis.

How to cite : Gupta A, Rajput D, Sodani S , Mutha A , Comparison of CRP with blood culture in the diagnosis of neonatal septicaemia. Indian J Microbiol Res 2020;7(4):327-329

Copyright © 2020 by author(s) and Indian J Microbiol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (

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