Fosfomycin susceptibility among ESBL producing gram negative bacilli causing urinary tract infections

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Author Details : Rajeshwari K G*

Volume : 8, Issue : 2, Year : 2021

Article Page : 142-145

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Urinary tract infection is one of the common infection encountered in day to day practice. Due to emergence of drug resitance among uropathogens treatment options have become limited. Fosfomycin being a safe oral antibiotic is being used widely to treat multidrug resistant uropathogens. In the present study 831 (48.45%) samples that yielded significant growth were processed out of 1715 sample for ESBL detection by double disc synergy and phenotypic confirmatory method. E.coli constituted the predominant isolate (60.4%) followed by K.pneumoniae. 256 (30.80%) samples yielding growth were from out patients and 575 from inpatients. Over all 44% of isolates in the present study were ESBL producers. 50% of Ecoli were ESBL producers. 70.64% of ESBL isolates were susceptible to fosfomycin in vitro. Present study finding suggest that resistance to fosfomysin is on rise even though majority of ESBLs were sensitive to it. The current study recommends to use fosfomycin only after testing susceptibility among uropathogens.

Keywords : Ecoli, ESBL, Fosfomysin, Kpneumoniae

How to cite : Rajeshwari K G, Fosfomycin susceptibility among ESBL producing gram negative bacilli causing urinary tract infections. Indian J Microbiol Res 2021;8(2):142-145

Copyright © 2021 by author(s) and Indian J Microbiol Res. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (

Article History

Received : 28-06-2021

Accepted : 28-06-2021

Available online : 30-07-2021

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