Exploring application & recent advances of response surface methodology driven approach in drug design and nanotechnology

• Author Details:   
• Aradhana Panigrahi
• Bikash Ranjan Jena ^*
• Surya Kanta Swain
• Himansu Bhusan Samal
• Pratap Kumar Patra

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The response surface methodology (RSM) continues to gain better importance in the current scenario in pharmaceutical analytical/formulation R & D, and healthcare industries including nanotechnology for its statistical implementation using diverse designs. The present review signifies the different types of RSM driven techniques, counting its combinations with analytical procedures and related guidelines on the methods for obtaining the ICH Q2(R1), ICH Q8, Q9, Q10 criteria’s by implementing a quality-by-design systematic holistic approach for product development. Apart from these, the comprehensive glance of the broadest applications of RSM approach in the nanotechnology and nano biotechnology are the major focus in this review. For utmost patient safety the GMP, quality assurance approved regulations provided ICH, WHO, and USFDA becomes more concern about current challenges, future prospectives of RSM driven novel evolving techniques in nanotechnology and nano biotechnology. Current review forecasts the broadest applications of RSM enabled liquid chromatographic hyphenated methodologies, screening risk assessment methodologies, regulatory significances, diversified formulations, analytical and casing bioanalytical method development, validations, stability studies to ascertain sustainable and economic product for better efficacy and patient compliance.

Keywords: Response surface methodology, Pharmaceutical, Nanotechnology, Screening.